123I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
Identifieur interne : 003615 ( Main/Exploration ); précédent : 003614; suivant : 003616123I‐Ioflupane SPECT in the diagnosis of suspected psychogenic Parkinsonism
Auteurs : Carles Gaig [Espagne] ; Maria José Martí [Espagne] ; Eduardo Tolosa [Espagne] ; Francesc Valldeoriola [Espagne] ; Pilar Paredes [Espagne] ; Francisco Juan Lome A [Espagne] ; Fernando Nakamae [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
English descriptors
- KwdEn :
- 123I‐Ioflupane SPECT, Adult, Aged, DAT imaging, Female, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (pharmacokinetics), Male, Middle Aged, Parkinsonian Disorders (diagnosis), Parkinsonian Disorders (etiology), Parkinsonian Disorders (radionuclide imaging), Psychotic Disorders (complications), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), Tropanes (pharmacokinetics), parkin gene mutation, psychogenic Parkinsonism.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Tropanes.
- chemical , pharmacokinetics : Iodine Radioisotopes, Tropanes.
- complications : Psychotic Disorders.
- diagnosis : Parkinsonian Disorders.
- etiology : Parkinsonian Disorders.
- radionuclide imaging : Parkinsonian Disorders.
- Adult, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21062
Affiliations:
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Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-11">2006-11</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1994">1994</biblScope><biblScope unit="page" to="1998">1998</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8963D2E53E502495B9D3CBAFC4500CD431C96CA0</idno><idno type="DOI">10.1002/mds.21062</idno><idno type="ArticleID">MDS21062</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>123I‐Ioflupane SPECT</term><term>Adult</term><term>Aged</term><term>DAT imaging</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Iodine Radioisotopes (pharmacokinetics)</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (diagnosis)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Psychotic Disorders (complications)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term><term>Tropanes (pharmacokinetics)</term><term>parkin gene mutation</term><term>psychogenic Parkinsonism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Iodine Radioisotopes</term><term>Tropanes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Iodine Radioisotopes</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Psychotic Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Psychogenic Parkinsonism (PsyP) can be clinically difficult to differentiate from Parkinson's disease (PD). Striatal dopamine transporter (DAT) imaging could be helpful in differentiating them. We performed 123I‐Ioflupane single‐photon emission computed tomography (SPECT) in 9 patients with suspected PsyP. In 1 patient, 123I‐Ioflupane SPECT disclosed bilateral decrease of striatal tracer uptake that indicated nigrostriatal degeneration. In this patient, a parkin gene mutation was detected. In the other 8 patients, 123I‐Ioflupane SPECT was normal and supported the initial suspicion of PsyP. Normal DAT imaging supports the diagnosis of PsyP, whereas reduced striatal tracer uptake suggests an underlying neurodegenerative Parkinsonism and should encourage the search for additional causes for the syndrome. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name></region><name sortKey="Lome A, Francisco Juan" sort="Lome A, Francisco Juan" uniqKey="Lome A F" first="Francisco Juan" last="Lome A">Francisco Juan Lome A</name><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name><name sortKey="Nakamae, Fernando" sort="Nakamae, Fernando" uniqKey="Nakamae F" first="Fernando" last="Nakamae">Fernando Nakamae</name><name sortKey="Paredes, Pilar" sort="Paredes, Pilar" uniqKey="Paredes P" first="Pilar" last="Paredes">Pilar Paredes</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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